{"api_version":"1.0.0","engine_version":"IndoVarClassifier-v1.0","status":"grant_research_pipeline_live","endpoints_live":["POST /indovar_v2/classify","POST /indovar_v2/demo/{case_name}","GET /indovar_v2/demo_cases","GET /indovar_v2/curated_substrate","GET /indovar_v2/citations","GET /indovar_v2/version"],"demo_case_ids":["arjun","meena","priya","rajan"],"methods":{"esm":"BLOSUM62 + Shannon-entropy conservation (ESM-2 compatible; swap-in documented)","population":"Ensembl VEP REST + gnomAD v4 GraphQL + ClinVar NCBI eUtils + IndiGen proxy","graph":"NetworkX PGx knowledge graph with CPIC / PharmGKB / IMPPAT sourced edges","synthesis":"Deterministic rule-based tier assignment; no LLM in the clinical path"},"curated_substrate_size":{"indigen_variants":16,"protein_sequences":5,"pgx_graph_nodes":62,"pgx_graph_edges":54},"publication_citations_count":10}