{"engine_version":"trust-audit-2026.07","enum_source":"api/trust_audit.py :: ConfidenceTier","tiers":[{"value":"validated","description":"Literature-sourced or CPIC-graded. Every fact traces to a named database record or publication. Safe for direct clinical decision support.","clinical_surface_safe":true},{"value":"wet_lab_confirmed","description":"Wet-lab measurement from a partner (Precigenetics-style). Structural Intelligence Tier 4. Safe for clinical decision support once the measurement is documented in the graph as a :TARGETS or :Variant.effect.","clinical_surface_safe":true},{"value":"structurally_predicted","description":"Boltz-2 co-folding / ESM zero-shot inference (or Phase 1 proxies). Structural Intelligence Tier 2 or Tier 3. HYPOTHESIS - never surfaces through clinical module read paths.","clinical_surface_safe":false},{"value":"gnn_predicted","description":"Discovery module graph-topology link prediction / node classification. HYPOTHESIS - never surfaces through clinical module read paths.","clinical_surface_safe":false},{"value":"simulated_distribution","description":"CardioRisk Monte Carlo output. Deterministic given rng_seed. Distributional risk estimate, not an individual clinical probability.","clinical_surface_safe":true},{"value":"deterministic_routing","description":"Orchestration router rule fire. Same input -> same routing decision every call. No LLM in the routing path.","clinical_surface_safe":true},{"value":"unclassified","description":"Explicit unknown. No sourced classification available for this output.","clinical_surface_safe":false}],"consistency_note":"Risk sec.6 §2: this enum is the single source of truth. Any module PRD that references confidence_tier terminology must reference these exact values - no module redefines its own vocabulary."}