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abacavir HSR mechanism","india_note":null},"HLA-B*58:01":{"supertype":"B58","coverage_tier":"moderate","p2_anchors":{"A":0.9,"T":0.9,"S":0.7},"p9_anchors":{"W":1,"F":0.9,"Y":0.7},"citation":"Barber et al. 1997; CPIC allopurinol SCAR gate","india_note":null},"HLA-B*13:01":{"supertype":"B13","coverage_tier":"moderate","p2_anchors":{"A":0.9,"S":0.7},"p9_anchors":{"F":0.9,"L":0.7,"W":0.6},"citation":"Zhang et al. 2013 dapsone DRESS","india_note":"Elevated Indian tribal populations"},"HLA-B*27:05":{"supertype":"B27","coverage_tier":"high","p2_anchors":{"R":1},"p9_anchors":{"L":0.8,"F":0.7,"K":0.6,"R":0.6},"citation":"Rammensee 1999; ankylosing spondylitis association","india_note":null}},"iedb_validated_pairs_count":10,"iedb_validated_pairs":[{"peptide":"AGFKGEQGP","hla_allele":"HLA-A*02:01"},{"peptide":"ENPVVHFFK","hla_allele":"HLA-A*11:01"},{"peptide":"GVYATRSSA","hla_allele":"HLA-A*02:01"},{"peptide":"HCLGKWLGH","hla_allele":"HLA-A*02:01"},{"peptide":"LYQLENYCN","hla_allele":"HLA-A*24:02"},{"peptide":"MEVGWYRSP","hla_allele":"HLA-A*02:01"},{"peptide":"NFFRMVISN","hla_allele":"HLA-A*02:01"},{"peptide":"SHLVEALYL","hla_allele":"HLA-A*02:01"},{"peptide":"VHFFKNIVT","hla_allele":"HLA-A*02:01"},{"peptide":"VLYRYGSFS","hla_allele":"HLA-A*02:01"}],"dnabert2_novel_allele_candidates":["HLA-B*13:01","HLA-B*15:02","HLA-B*58:01"],"confidence_tier_scheme_prd_6_3":{"Validated":"IEDB experimental pair","Predicted-high-confidence":"Novel pair, HLA in high-coverage panel","Predicted-low-confidence":"Novel pair, HLA under-represented (DNABERT-2 territory)","TolerogenicContext":"ALWAYS flagged separately as heuristic — never blurred with binding tier"}}