G6PD Orissa (c.131C>G, p.Ser44Cys) is found in ~97.9% of G6PD-deficient individuals screened in tribal Odisha PVTG populations. WHO Class II severe deficiency. Primaquine and tafenoquine — the only radical-cure drugs for P. vivax malaria — carry high acute hemolysis risk in these patients. No existing tool scores Indian-specific G6PD variants for structural severity. This is Phase 1.
Phase 1 today — curated Indian G6PD variant knowledge + WHO class alignment + primaquine/tafenoquine guidance per severity tier + regional epidemiology overlay. Phase 1b plugs into the same API contract — local ESM1b masked-marginal scoring per PRD §5.2 (fair-esm + esm1b_t33_650M_UR50S weights + UniProt P11413 canonical sequence + Legion 5 RTX 3060 6GB VRAM adequate for fp16 inference). ESM scores here are WHO-class-derived placeholders per PRD §11 no-fabrication policy.
ESM scores displayed here are WHO-class-derived placeholders — replaced with live esm1b_t33_650M_UR50S masked-marginal output when Phase 1b (local GPU inference) lands. Frequencies with verification_required=true need PMID confirmation against primary Indian tribal screening literature before customer-facing use.
The IndoG6PD phase stack
Same-API-contract expansion. Phase 1b, 2, 3 all plug into POST /g6pd/check — adopters integrating today won't need to rewrite when live inference or hemoglobinopathy modules land.
Phase 1 · live
Curated variant knowledge layer
Indian G6PD variants (Orissa dominant) + WHO class alignment + primaquine/tafenoquine guidance + regional epidemiology. NO fabricated data (PRD §11). Placeholder ESM scores.